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Öğe Current perspectives on the role of oxytocin receptor (OXTR) gene variants in panic disorder: associations with disease liability and separation anxiety(Termedia Publishing House Ltd, 2026) Yegin, Zeynep; Sarisoy, Gokhan; Uzun, Ahmet; Altinisik, YasinIntroduction: Oxytocin receptor (OXTR) gene variations are associated with empathy, trust, emotional stability, stress reactivity, social bonding and attachment behaviors. We aimed to explore the impact of three OXTR gene variations (rs53576, rs237902, rs2254298) in susceptibility to panic disorder (PD). We also investigated the possible effects of these variants on separation anxiety scale scores in patients, with a comprehensive approach covering environmental adversity effects. Material and methods: The hypothesis was studied in PD patients and healthy controls with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. By applying the Separation Anxiety Symptom Inventory (SASI) and the Adult Separation Anxiety Questionnaire (ASA), the relationships between the OXTR gene variants and these scales were also evaluated comprehensively. Results: A statistically significant association was found for OXTR rs237902; presence of the A allele was associated with a 1.585-fold increase in probability of PD. Moreover, all of the analyzed OXTR variants were found to be associated with childhood and adult separation anxiety in the patients in the combined analyses of various demographic and clinical data; striking associations of AA genotype with SASI and ASA scores were observed in these models. Conclusions: The study supports the involvement of oxytocinergic gene variants in PD. It also represents one of the most comprehensive models examining gene-environment (G & times; E) interactions in this context.Öğe Role of miRNA Gene Variants (miR-22 and miR-155) as the Factors Affecting Susceptibility to Panic Disorder(Korean Coll Neuropsychopharmacology, 2024) Yegin, Zeynep; Sarisoy, Gokhan; Uzun, Ahmet; Koc, HaydarObjective: Variants within genes encoding microRNAs (miRNAs) may alter the expression of both miRNAs and their target genes, thus contributing to the etiology of psychiatric disorders. The involvement of miRNAs in neuronal differentiation and synaptic plasticity supported this hypothesis. We aimed to investigate the links between miR-155 rs767649/miR-22 rs8076112 and the risk of panic disorder (PD) in a sample of Turkish population. Methods: In this experimental study, 134 PD patients and 140 healthy controls were recruited. Genotyping was carried out using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. To evaluate PD phenotypes, Panic Disorder Severity Scale (PDSS) was also administered to patients to clarify possible associations between the scale and risk variants analyzed. Results: The genotype analysis of miR-155 rs767649 did not show an association with PD risk and it was not related to the disease severity. For miR-22 rs8076112 variant, a statistically significant association was determined; CC genotypes were lower in patients compared to controls. Logistic regression analysis proved the highly protective effect (80.4%) of CC genotype against PD (p = 0.041; OR = 0.196, 95% CI = 0.041-0.934). Though its significance in disease liability, miR-22 rs8076112 was not associated with the disease severity. Conclusion: Our findings firstly report the combined analysis of miR-155 rs767649 and miR-22 rs8076112 in PD in terms of both disease susceptibility and severity. These findings await replication in independent cohorts with enrichment of other miRNA gene variants. Thus, certain miRNAs and their target genes involved in the etiology and phenotypes of PD could be enlightened.
