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    Öğe
    Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients
    (Springer, 2018) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecioglu, Onder; Demir, Mustafa
    The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group.
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    Öğe
    Determination of Se, Cr, Mn, Zn, Co, Na, and K in Blood Samples of Breast Cancer Patients to Investigate Their Variation Using ICP-MS and ICP-OES
    (Atomic Spectroscopy Press Ltd, 2019) Toker, Ozan; Topdagi, Omer; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecloglu, Onder; Karabul, Yasar
    The aim of this study was to investigate the concentration changes of Se, Mn, Cr, Zn, Co, Na and K in blood samples of breast cancer patients. Determination of the elements was performed using ICP-MS and ICP-OES instruments. Kolmogorov-Smirnov normality tests, Mann-Whitney U tests, Independent sample T tests and Spearman's rank correlation tests were performed for statistical comparisons. It was found that the concentrations of Na and K in breast cancer patients were higher than for healthy people. The Se, Mn, and Cr concentrations were found to be lower in patients with breat cancer. No increase/decrease in Zn concentrations between the two groups was observed. A positive correlation was found between the distribution of Zn and K elements. Independent sample t and Mann-Whitney U tests demonstrated that statistical differences were observed between patients having the diagnosis of breast cancer and healthy people in terms of the concentrations of Se, Cr and Na. The results presented in this study will contribute to the literature by showing the relationship between breast cancer and element concentrations.
  • [ X ]
    Öğe
    Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer
    (Atomic Spectroscopy Press Ltd, 2020) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Oz, Ersoy; Bursalioglu, Ertugrul Osman; Abuqbeitah, Mohammad; Demir, Mustafa
    The main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca).