Yazar "Singh, Gurjaspreet" seçeneğine göre listele

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    Öğe
    Diazenyl-hydrazone functionalized silatrane hybrids: Integrating structural precision for Al (III) sensing and anticancer activity
    (Elsevier, 2026) Singh, Gurjaspreet; Heena; Meral, Seher; Markan, Pallavi; Kaur, Harshbir; Gill, Baljinder Singh; Baliyan, Deepanjali
    This manuscript investigates the synthesis and potential of a silatrane-tethered hydrazone derivative as a multifunctional compound capable of selective metal ion sensing, anticancer activity. The synthesized compound demonstrated high sensitivity and selectivity for Al(III) through UV-Vis and fluorescence spectroscopy with 18.73 and 3.46 nM LOD values, respectively, highlighting its effectiveness as a chemosensor. Additionally, both in-vitro and in-silico studies confirmed its promising anticancer properties. The integration of the silatrane framework with the hydrazone moiety enhanced the stability and optical properties of the compound, positioning it as a versatile candidate for addressing key challenges in environmental monitoring and therapeutic interventions. The results indicate that the silatrane-tethered hydrazone holds significant promise for applications in metal ion detection, cancer treatment, providing a foundation for further exploration and development of multifunctional systems with dual sensing and therapeutic roles.
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    Öğe
    Organosilane Functionalized Graphene Oxide Nanocomposite as Fluorescent Chemosensor for the Detection of Tyrosine in Aqueous Medium
    (Wiley, 2025) Singh, Gurjaspreet; Devi, Swati; Singh, Akshpreet; Sharma, Samiksha; Sharma, Devina; Markan, Pallavi; Kaur, Harshbir
    In the present article, a selective and efficient sensor based on organosilane functionalized graphene oxide nanocomposites has been synthesized for the fluorometric detection of tyrosine (Tyr). The 1,2,3-triazole functionalized organosilane has been synthesized by a condensation reaction between 4-(methylthio) aniline and alkylated benzaldehyde followed by azide-alkyne cycloaddition reaction using Cu (I) catalyst. The synthesized organosilane has been fabricated on graphene oxide nanoparticles and the obtained graphene-functionalized organosilane (GO-Silane) was characterized by FTIR and XRD. The morphology of the nanocomposite film was analyzed using scanning electron microscopy. The photophysical properties of GO-Silane were studied which established its selective sensor for tyrosine with the limit of detection values of 1.04 x 10-8 M with a response time of 8 s. The strong coordinated interactions of GO-Silane for the Tyr have been confirmed from FTIR spectra of the GO-Silane-Tyr complex. The competitive amino acid interference assay successfully demonstrated the selectivity of the nanocomposite sensor.