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    Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients
    (Springer, 2018) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecioglu, Onder; Demir, Mustafa
    The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group.
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    Determination of Se, Cr, Mn, Zn, Co, Na, and K in Blood Samples of Breast Cancer Patients to Investigate Their Variation Using ICP-MS and ICP-OES
    (Atomic Spectroscopy Press Ltd, 2019) Toker, Ozan; Topdagi, Omer; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecloglu, Onder; Karabul, Yasar
    The aim of this study was to investigate the concentration changes of Se, Mn, Cr, Zn, Co, Na and K in blood samples of breast cancer patients. Determination of the elements was performed using ICP-MS and ICP-OES instruments. Kolmogorov-Smirnov normality tests, Mann-Whitney U tests, Independent sample T tests and Spearman's rank correlation tests were performed for statistical comparisons. It was found that the concentrations of Na and K in breast cancer patients were higher than for healthy people. The Se, Mn, and Cr concentrations were found to be lower in patients with breat cancer. No increase/decrease in Zn concentrations between the two groups was observed. A positive correlation was found between the distribution of Zn and K elements. Independent sample t and Mann-Whitney U tests demonstrated that statistical differences were observed between patients having the diagnosis of breast cancer and healthy people in terms of the concentrations of Se, Cr and Na. The results presented in this study will contribute to the literature by showing the relationship between breast cancer and element concentrations.
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    Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer
    (Atomic Spectroscopy Press Ltd, 2020) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Oz, Ersoy; Bursalioglu, Ertugrul Osman; Abuqbeitah, Mohammad; Demir, Mustafa
    The main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca).
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    Evaluation of magnetic field assisted sun drying of food samples on drying time and mycotoxin production
    (Elsevier Sci Ltd, 2019) Nuroglu, Emine; Oz, Ersoy; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Kavanoz, Huseyin Birtan; Icelli, Orhan
    Mycotoxins are a variety of metabolic products produced by fungi, which can cause various damages to other organisms. The aim of this study was to figure out the effect of new drying methods namely drying in oven under magnetic field and drying under the sun and magnetic field on the mycotoxin formation for some food samples. In this system, a fixed magnetic field of 300 mu T was used for the drying process. The amounts of moisture in the samples dried with the new developed methods were measured in hazelnut (Corylus L.), fig (Ficus calico L.), chili pepper (Capsicum annuum L.) and grape (Vitis vinifera L.) depending on time. Mycotoxin species within different foodstuffs were determined at trace levels by using LC-MS/MS device under the optimum conditions, and the results obtained from the samples dried with the new methods were compared with each other and results of food samples dried by traditional method. The results indicated that the new developed drying methods cause decrease in the drying periods, and the dried samples did not contain any mycotoxin. This study suggested new drying strategies to eliminate the mycotoxin formation. For the analysis of the results, different statistical tests were used. In order to determine which technique works faster in drying the samples, box plots were obtained using descriptive statistics. Mann Whitney tests were also applied to determine if there was a statistical difference between the drying methods.
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    Prediction of electron density and trace element concentrations in human blood serum following radioiodine therapy in differentiated thyroid cancer patients
    (Elsevier Sci Ltd, 2017) Bursalioglu, Ertugrul O.; Alkan, Fatma A.; Barutcu, Umit B.; Demir, Mustafa; Karabul, Yasar; Balkan, Begum; Oz, Ersoy
    The aim of this study is to investigate trace element levels (Cr, Cu, Fe, Mg, Mn, Se, Zn, As, B, Si and Co) in serum samples of patients with papillary thyroid cancer. The analysis of trace elements levels of samples carried out using ICP-OES. Elements in blood samples were determined by ICP-OES after using Hettich Universal Centrifuge and differences between the values of Zn, Mg, Fe and Cu of blood samples were obtained pre -therapy and post -therapy. The concentrations of elements were normalized to percentage. Later, electron densities (N-el) of blood samples have been determined using ZXCOM program. A venture was made to perform a correlation between electron density and pre -posttreatment. This attempt is quite new in literature. Interestingly, it was generally observed that the electron densities of blood samples posttreatment are higher than pretreatment. Among elements, normalized concentration values of Cu and electron densities were in particular compared with patient type. Also, statistical analysis of blood results was achieved for 11 patients and 11 normal individual as control group for pre-posttreatment. Wilcoxon test which is a non -parametric test was used. 2016 Elsevier Ltd. All rights reserved.