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    Combined experimental and theoretical study of the novel ferrocene derivatives and examining the effect of E-Z stereoisomerism on their optical properties
    (Elsevier Science Bv, 2019) Aslan, Hakan; Kurtay, Gulbin; Korkmaz, Adem; Cetin, Adnan; Oktemer, Atilla
    Herein, we present the primary results on two valuable E-Z stereoisomers containing ferrocene scaffold [(E)-5,5-dimethy1-3-oxo-2-(2-phenyl-2-ferrocenyl-vinyl)cyclohex-1-en-1-yl acetate (E-FerCycAc) and its Z-stereoisomer (Z-FerCycAc)]. These compounds were both prepared from 1-phenylvinyl-ferrocene and 5,5-dimethyl-1,3-cyclohexanedione under catalysis of manganese(III) acetate according to the radical addition mechanism. The prominent spectroscopic data of the target stereoisomers were provided by FT-IR, LC-MS, (1) H NMR, (13) C NMR techniques, and their stereochemical identification was made primarily by NOESY analysis. The corresponding data (absorbance, transmittance and optical and transport energy gap) were collected from UV-vis studies. The optical properties of the glass slides coated with E-FerCycAc and Z-FerCycAc films were examined and consequently, the optical and transport energy band gap values of the E-FerCycAc were found significantly lower than Z-FerCycAc. The physicochemical and spectroscopic findings (HOMO-LUMO energies, bandgap values, UV-vis, FT-IR, (1) H, and (13) C NMR spectra) were also compared and supported with the acquired DFT calculations.
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    Multifunctional therapeutic hybrid nanocarriers for targeted and triggered drug delivery: recent trends and future prospects
    (Elsevier, 2017) Kurtay, Gulbin; Yılmaz, Mehmet; Kuralay, Filiz; Demirel, Gokcen B.
    Cancer is certainly among the most traumatic diseases with the addition of more than ten million new cases every year. The usage of chemotherapy agents is admissible as an effective treatment method despite of their well-known irreversible side effects to vital tissues and organs. In spite of the advancement in nanotechnology, which allows us to develop new generation nanocarriers, the human body is a very complex system and possesses many challenges such as biocompatibility, biodistribution, side effects, biological barriers, and so forth against drug delivery systems. In this regard, a perfectly designed nanocarrier should contain multifunctional properties to overcome these obstacles. Additionally, a smart nanocarrier system should deliver the drug to the specific place at the right dosage and time. Therefore, to develop this kind of smart therapeutic system, the desired properties such as imaging, diagnosis, and targeted delivery might be combined into a single system by fabrication of a hybrid nanocarrier. On this account, the hybrid nanocarriers have a promising potential to find application areas in the future of nanomedicine. In this chapter, we will discuss the new generation and promising hybrid nanocarriers based on noble metal, porous silica, polymer, and core–shell therapeutics, which exhibit active targeting, triggered release of cargo, and imaging capability for in vivo studies. © 2017 Elsevier Inc. All rights reserved.