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Synthesis, characterization, crystal structure, redox-reactivity and antiproliferative activity studies of Cu(II) and Pd(II) complexes with F, CF3 bearing 3,5-di-tert-butylsalicylaldimines
(Pergamon-Elsevier Science Ltd, 2016) Kasumov, Veli T.; Sahin, Onur; Aktas, Hatice Gumushan
In this work, based on 3,5-di-tert-butyl-2-hydroxybenzaldehyde and F, CF3-substituted anilines [2-fluoro-3-(trifluromethyl)aniline, 2-fluoro-5-(trifluromethyl)aniline, 3,5-bis(trifluoromethylaniline and 2-fluoro-3-(trifluromethyl)benzylaniline], the corresponding salicylaldimine ligands (HLx, X = 1, 2, 3, 4) and their CuL2x and PdL2x complexes were synthesized. The structures of these compounds were characterized by spectroscopic (IR, UV/Vis, H-1 and F-19 NMR, ESR) and X-ray diffraction techniques. Chemical oxidation of the tert-buylated HLx ligands and their CuLx2 complexes using Ce(IV) under anaerobic and aerobic conditions at room temperature (r.t.) in DMF solution revealed the generation of phenoxyl radicals. An X-ray structural study revealed that thanks to CH....F and CH.....pi bonds both the CuL21 and PdL21 molecules crystallize as hydrated dimers that pack differently. The antiproliferative potentials of all the compounds against Mat-LyLu cell lines were determined. (C) 2016 Elsevier Ltd. All rights reserved.