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    EFFECT OF ZINC SULPHATE ON THE LEVELS OF PLASMA PARAOXONASE ACTIVITY, TOTAL OXIDANT AND HIGH DENSITY LIPOPROTEIN OF TRANSCAUCASIAN BARB (Capoeta capoeta [Guldenstaedt, 1773])
    (Parlar Scientific Publications (P S P), 2015) Deveci, Haci Ahmet; Kaya, Inan; Yilmaz, Muhittin; Karapehlivan, Mahmut
    Zinc and its compounds have different effects in chemical or toxicological terms on many living species in the aquatic areas. In this study, total plasma paraoxonase activity (PON1), total oxidant (TOS) and high density lipoprotein (HDL) levels in response to different doses of zinc sulphate (ZnSO4) in Capoeta capoeta were investigated. The fishes were kept in tanks for 15 days for adaptation. Three groups of fish (control, 1st and 2nd), each containing nine fishes, were placed in separate tanks containing no 5 and 10 mg/L ZnSO4, respectively for 10 days. At the end of the study, blood samples were taken, and plasma PON1, TOS and HDL levels were analyzed. An increase in plasma TOS level was found along with increasing ZnSO4 amounts compared to the control group, and a decrease in PON1 and HDL levels was observed. In conclusion, it was determined that levels of PON1, TOS and BDL were altered depending on ZnSO4 doses applied in Capoeta capoeta.
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    Effect of zinc sulphate on the levels of plasma paraoxonase activity, total oxidant and high density lipoprotein of transcaucasian barb: (Capoeta capoeta [Guldenstaedt, 1773])
    (Parlar Scientific Publications, 2015) Deveci, Haci Ahmet; Kaya, Inan; Yilmaz, Muhittin; Karapehlivan, Mahmut
    Zinc and its compounds have different effects in chemical or toxicological terms on many living species in the aquatic areas. In this study, total plasma paraoxonase activity (PON1), total oxidant (TOS) and high density lipoprotein (HDL) levels in response to different doses of zinc sulphate (ZnSO4) in Capoeta capoeta were investigated. The fishes were kept in tanks for 15 days for adaptation. Three groups of fish (control, 1st and 2nd), each containing nine fishes, were placed in separate tanks containing no 5 and 10 mg/L ZnSO4, respectively for 10 days. At the end of the study, blood samples were taken, and plasma PON1, TOS and HDL levels were analyzed. An increase in plasma TOS level was found along with increasing ZnSO4 amounts compared to the control group, and a decrease in PON1 and HDL levels was observed. In conclusion, it was determined that levels of PON1, TOS and HDL were altered depending on ZnSO4 doses applied in Capoeta capoeta.
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    EFFECTS OF GLYPHOSATE (HERBICIDE) ON SERUM PARAOXONASE ACTIVITY, HIGH DENSITY LIPOPROTEIN, TOTAL ANTIOXIDANT AND OXIDANT LEVELS IN KARS CREEK TRANSCAUCASIAN BARBS (CAPOETA CAPOETA [GULDENSTAEDT, 1773])
    (Parlar Scientific Publications (P S P), 2017) Deveci, Haci Ahmet; Unal, Sevgi; Karapehlivan, Mahmut; Ayata, Muradiye Karasu; Gaffaroglu, Muhammet; Kaya, Inan; Yilmaz, Muhitdin
    The aim of this study is to explore the effects of the herbicide glyphosate on serum paraoxonase (PON1) activity, high-density lipoprotein (HDL), and total antioxidant (TAS) and oxidant (TOS) levels in Kars Creek Transcaucasian Barbs (Capoeta capoeta [Guldenstaedt, 1773]). Twenty four Capoeta capoeta are chosen within a weight range of 200 to 240 grams and they are equally divided into 3 groups, namely Groups I, II, III. The fish placed in Group I are received aquatic environment while Groups II and III were kept in aquatic environments with a pH value of 7.4 in tanks to which 0,01 and 0,02 mg/L glyphosate (N-phosphonomethyl glycine 480 mg/L), respectively. It was found that groups II and III had significantly lower serum plasma PON1, HDL and TAS levels than the control group (Group I). On the other hand, serum TOS levels were found significantly elevated in Groups II and III, in comparison to the control group. In this work, significant changes were found in the serum paraoxonase activity, HDL, TAS and TOS levels of fishes living in environments added 0.01 and 0.02 mg/L glyphosate.
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    Effects of Zinc Sulphate on Transcaucasian Barb, (Capoeta capoeta [Guldenstaedt, 1773]) Plasma Nitric Oxide, Malondialdehyde and Total Sialic Acid Levels
    (Kafkas Univ. Veteriner Fakültesi Dergisi, 2012) Yılmaz, Muhittin; Karapehlivan, Mahmut; Kaya, İnan
    The aim of this study was to investigate plasma total sialic acid (TSA), nitric oxide (NO) and malondialdehyde (MDA) levels in response to different doses of zinc sulphate (ZnSO4) in Capoeta capoeta. The fishes were kept in tanks for 15 days for adaptation. Three groups of fish (control, 1st, and 2nd), each containing 9 fishes, were placed in separate tanks containing no, 5 and 10 mg/L ZnSO4, respectively for 10 days. At the end of the study, blood samples were taken, and plasma TSA, NO and MDA levels were analyzed. An increase in plasma TSA and MDA levels were found along with increasing ZnSO4 amounts, and a decrease in NO levels was observed. In conclusion, it was determined that levels of TSA, MDA and NO were altered depending on ZnSO4 doses applied in C. capoeta.
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    THE EFFECT OF TEBUCONAZOLE ON SERUM PARAOXONASE AND AMINOTRANSFERASE ACTIVITIES IN CYPRINUS CARPIO (L. 1758)
    (Parlar Scientific Publications (P S P), 2017) Nur, Gokhan; Yilmaz, Muhitdin; Karapehlivan, Mahmut; Kaya, Ivan; Nur, Ozlem; Deveci, Ayla
    The purpose of this study was to examine serum paraoxonase (PON1), alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity and high density lipoprotein (HDL) levels of tebuconazole administered Cyprinus carpio (L. 1758). After providing adaptation of the fish in the laboratory setting for 7 days, they were divided into 3 groups, each of which included 8 fish. The fish in Group I were kept in normal water environment and those in Groups II and III were in 2 and 3 mg/L tebuconazole added water tanks, respectively, for 14 days. Blood samples were taken from the fish and serums were separated. Then, PON1, ALT, and AST activities and HDL levels were analyzed. While PON1 activity and HDL levels decreased in tebuconazole administered groups compared to Group I, increases were determined in terms of ALT and AST. Consequently, it was found that tebuconazole administrations caused significant changes in serum PON1, ALT, and AST activities and HDL levels of Cyprinus carpio.
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    The Effects of Carbaryl and 2,4-Dichlorophenoxyacetic Acid on Oxidative Stress Index in Capoeta capoeta (Guldensteadt 1773)
    (Zoological Soc Pakistan, 2019) Kaya, Inan; Yilmaz, Muhitdin; Kaya, Muge Mavioglu; Kukurt, Abdulsamed; Karapehlivan, Mahmut
    The aim of the present study is to investigate the oxidative stress index in Capoeta capoeta treated with carbaryl and 2,4-dichlorophenoxyacetic acid (2,4-D). Fifty Capoeta capoeta fish caught in Kars Creek were equally divided into five groups and acclimatized in separate tanks for 10 days. The fish were kept in tanks as follows: Group I (control) was kept in normal water. Group II, III, IV and V were kept in separate tanks containing 0.3 mg/L carbaryl, 0.6 mg/L carbaryl, 10 mg/L 2,4-D and 20 mg/L 2,4-D, respectively. The blood and liver samples were taken from the fish for biochemical studies at the end of the study period. Oxidative stress index (OSI) in plasma were evaluated as well as AST and ALT levels in the liver. Plasma OSI and liver AST levels in the groups with carbaryl and 2,4-D were compared with the control group, and they were found to be significantly higher. As a result, it was concluded that carbaryl and 2,4-D administered under of LC50 value caused liver damage by increasing the oxidative stress of Capoeta capoeta.