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    The effect of thrombosis-related laboratory values on mortality in COVID-19 infection
    (Verduci Publisher, 2023) Ergenc, Z.; Ergenc, H.; Ozturk, A.; Kaya, T.; Nalbant, A.; Karacaer, C.; Gunay, S.
    OBJECTIVE: COVID-19 may cause thrombosis in both venous and arterial systems. Familiarity with the signs and symp-toms of thrombosis and its treatment is essen-tial in treating COVID-19 infection and its com-plications. D-Dimer and mean platelet volume (MPV) are measurements related to the devel-opment of thrombosis. This study investigates whether MPV and D-Dimer values could be used to determine the risk of thrombosis and mortali-ty in the COVID-19 early stages.PATIENTS AND METHODS: 424 patients who were COVID-19 positive, according to the World Health Organization (WHO) guidelines, were randomly and retrospectively included in the study. Demographic and clinical character-istics such as age, gender, and length of hospi-talization were obtained from the digital records of participants. Participants were divided into living and deceased groups. The patients' bio-chemical, hormonal, and hematological param-eters were analyzed retrospectively.RESULTS: White blood cells (WBC), neutro-phils, and monocytes were significantly differ-ent in the two groups (p-value <0.001), and their values were lower in the living group than in the deceased group. MPV median values did not dif-fer according to prognosis (p-value = 0.994). While the median value was 9.9 in the survivors, it was 10 in the deceased. Creatinine, procalci-tonin, ferritin, and the number of hospitalization days in living patients were significantly lower than in patients who died (p-value <0.001). Me-dian values of D-dimer (mg/L) differ according to prognosis (p-value <0.001). While the median value was 0.63 in the survivors, it was found as 438 in the deceased.CONCLUSIONS: Our results did not show any significant relationship between the mortality of COVID-19 patients and their MPV levels. How-ever, a significant association between D-Di-mer and mortality in COVID-19 patients was ob-served.