Yazar "Demir, Mustafa" seçeneğine göre listele

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    Contamination Measurements of Patient’s Lead-Insulated Rooms After I- 131 and LU-177 PSMA Treatment via Sweeping Test
    (2018) Harman, Kubra; Demırbay, Tuğba; Demir, Mustafa
    I-131 and Lu-177 PSMA radionuclides have been widely used in the field of nuclear medicine totreat thyroid cancer for many years. In this treatment, the patients whose dose rate measurements are less than3 mR/h are generally discharged from the lead-insulated rooms where they are hospitalized. The aim of ourstudy is to evaluate the contamination measurements of these rooms after I-131 and LU-177 PSMA treatmentand to ensure radiation safety. A sweeping test was carried out by using Whatman papers (10x10 cm2 in size)to take samples from designated areas of these rooms in which three patients were treated with Lu-177 PSMAand four patients were treated with the I-131 radionuclide. Whatman papers are placed inside different tubes toprevent external contamination. Afterward, counting procedure was taken to the tubes for one minute by usingthe gamma counter which has different calibration factors both for Lu-177 and I-131 radionuclides. For thebackground extraction, one-minute counting test was applied to one of the Whatman papers that were not usedfor sweeping and background value was then obtained. It was statistically understood that the highestcontamination rate was observed on the surface of toilet potteries in each room. As a result, ventilation of theroom, meticulous cleaning of contaminated areas and the sweeping test must be implemented in each roomwhere the patients are treated with radionuclides before the treatment of other patients.
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    Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients
    (Springer, 2018) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecioglu, Onder; Demir, Mustafa
    The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group.
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    Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer
    (Atomic Spectroscopy Press Ltd, 2020) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Oz, Ersoy; Bursalioglu, Ertugrul Osman; Abuqbeitah, Mohammad; Demir, Mustafa
    The main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca).
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    Prediction of electron density and trace element concentrations in human blood serum following radioiodine therapy in differentiated thyroid cancer patients
    (Elsevier Sci Ltd, 2017) Bursalioglu, Ertugrul O.; Alkan, Fatma A.; Barutcu, Umit B.; Demir, Mustafa; Karabul, Yasar; Balkan, Begum; Oz, Ersoy
    The aim of this study is to investigate trace element levels (Cr, Cu, Fe, Mg, Mn, Se, Zn, As, B, Si and Co) in serum samples of patients with papillary thyroid cancer. The analysis of trace elements levels of samples carried out using ICP-OES. Elements in blood samples were determined by ICP-OES after using Hettich Universal Centrifuge and differences between the values of Zn, Mg, Fe and Cu of blood samples were obtained pre -therapy and post -therapy. The concentrations of elements were normalized to percentage. Later, electron densities (N-el) of blood samples have been determined using ZXCOM program. A venture was made to perform a correlation between electron density and pre -posttreatment. This attempt is quite new in literature. Interestingly, it was generally observed that the electron densities of blood samples posttreatment are higher than pretreatment. Among elements, normalized concentration values of Cu and electron densities were in particular compared with patient type. Also, statistical analysis of blood results was achieved for 11 patients and 11 normal individual as control group for pre-posttreatment. Wilcoxon test which is a non -parametric test was used. 2016 Elsevier Ltd. All rights reserved.
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    Radiation Dose to Technologists per Nuclear Medicine Examination and Estimation of Annual Dose
    (Soc Nuclear Medicine Inc, 2011) Bayram, Tuncay; Yilmaz, A. Hakan; Demir, Mustafa; Sonmez, Bircan
    Conventional diagnostic nuclear medicine applications have been continuously increasing in most nuclear medicine departments in Turkey, but to our knowledge no one has studied the doses to technologists who perform nuclear medicine procedures. Most nuclear medicine laboratories do not have separate control rooms for technologists, who are quite close to the patient during data acquisition. Technologists must therefore stay behind lead shields while performing their task if they are to reduce the radiation dose received. The aim of this study was to determine external radiation doses to technologists during nuclear medicine procedures with and without a lead shield. Another aim was to investigate the occupational annual external radiation doses to Turkish technologists. Methods: This study used a Geiger-Mu ller detector to measure dose rates to technologists at various distances from patients (0.25, 0.50, 1, and 2 m and behind a lead shield) and determined the average time spent by technologists at these distances. Deep-dose equivalents to technologists were obtained. The following conventional nuclear medicine procedures were considered: thyroid scintigraphy performed using Tc-99m pertechnetate, whole-body bone scanning performed using Tc-99m-methylene diphosphonate, myocardial perfusion scanning performed using Tc-99m-methoxyisobutyl isonitrile, and Tl-201 (thallous chloride) and renal scanning performed using Tc-99m-dimercaptosuccinic acid. Results: The measured deep-dose equivalent to technologists per procedure was within the range of 0.13 +/- 0.05 to 0.43 +/- 0.17 mu Sv using a lead shield and 0.21 +/- 0.07 to 1.01 +/- 0.46 mu Sv without a lead shield. Also, the annual individual dose to a technologist performing only a particular scintigraphic procedure throughout a year was estimated. Conclusion: For a total of 95 clinical cases (71 patients), effective external radiation doses to technologists were found to be within the permissible levels. This study showed that a 2-mm lead shield markedly reduced the external dose to technologists. The doses to technologists varied significantly for different diagnostic applications. Consequently, the estimated annual dose to a technologist performing only a particular scintigraphic procedure is very different from one type of procedure to another. The results of this study should help in determining the rotation time of technologists in different procedures and differences in their individual techniques.