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    Novel heteroleptic metal cation complexes of anisic acid/N, N-diethylnicotinamide ligands and biological applications
    (Elsevier, 2026) Cataldag, Esra; Kose, Dursun Ali; Ozluk, Gizem; Sahin, Onur
    Five different heteroleptic complex structures were synthesized by the coordination of anionic p-methoxybenzoate (anisate) and neutral N,N-diethylnicotinamide (niketamide) ligands to transition metal cations (Mn2+, Co2+, Ni2+, Cu2+ and Zn2+). The similarity of the spectroscopic and thermal properties of the Ni2+ cation-centered complex, whose single crystal structure was solved, to other complexes supports the suggestion that the structures are isostructural. Chemical composition analysis and other spectroscopic analysis results support the idea that the Cu2+ cation-centered structure, unlike the others, is in five-fold coordination. It is predicted that the six-fold coordination complexes (Mn2+, Co2+, Ni2+ and Zn2+) are coordinated by two anisate anions, two neutral nicotinamide ligands, and two crystal waters, while the Cu2+ structure is coordinated with a single crystal water content. It was also determined that the Co2+ and Zn2+ cation complexes possess hydrate waters bound to the coordination sphere by hydrogen bonds. Thermal decomposition curves support the presence of hydrate molecules within the structures. The antibacterial and antifungal properties of the structurally characterized molecules were investigated against biological agents such as Escherichia coliATCC 25,922, K. pneumoniae K6 ATCC 700,603, E. faecalis ATCC 29,212, S. epidermidis ATCC 12,228, and C. krusei ATCC 6258 using the disk diffusion method. The effectiveness of the Zn2+ complex compound against ampicillin-resistant K. pneumoniae strains can be considered significant.
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    Öğe
    Novel mixed-ligand metal complexes containing anisic acid/nicotinamide ligands. Their synthesis, structural characterization and biological applications
    (Pergamon-Elsevier Science Ltd, 2025) Cataldag, Esra; Kose, Dursun Ali; Ozluk, Gizem; Sahin, Onur
    In this study, five different p-methoxybenzoate (anisate)-nicotinamide complex compounds, whose central atoms are transition metal cations (Mn2+, Co2+, Ni2+, Cu2+ and Zn2+), were synthesized and their structural characterizations were investigated. In addition, the antibacterial and antifungal properties of the compounds against various biological derivatives were investigated by disk diffusion method. Elemental analysis, magnetic susceptibility, FTIR spectra, thermoanalytical TG-DTG/DTA analysis and single crystal X-ray diffraction methods were used to determine the structural characterizations of the compounds. It was determined that the complexes containing Co2+ and Ni2+ cations, whose single crystal structures were solved, were isostructured. It was suggested that the coordination properties of the other three coordination compounds centered on Mn2+, Cu2+ and Zn2+ were like the solved structures because of the similarity of thermal and spectroscopic analysis results. Due to the nature of the metal cation, it was predicted that only the Cu2+ complex was in fivefold coordination and the coordination was completed with two anisate anions, two neutral nicotinamide ligands and one crystal water. It was determined that the other four complex structures were in sixfold coordination and that they completed their coordination with one more crystal water, unlike the Cu2+ complex. It was also seen that the complex with the Co2+ central atom contained two hydrate waters, unlike the other complexes. The presence of water molecules in the coordination compounds and the thermal decomposition steps of the structures were determined by TG/DTA curves.