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    Antioxidant effect of sildenafil on cadmium-induced liver, lung and kidney injury
    (Society of Pharmaceutical Sciences of Ankara (FABAD), 2020) Baran, Ahmet Hüsamettin; Berk, Ahmet; Kaymaz, M. Bahadır; Aktay, Göknur
    The aim of this study is to investigate the protective effect of sildenafil against cadmium-induced liver, lung and kidney toxicity. In total of 28 Sprague Dawley female rats included in this study were divided into four groups: control, Sil, Cd, Sil+Cd groups. CdCl2 and Sil citrate were dissolved in distilled water, the injection volume adjusted to 0,5 ml / rat. On the 7th day, a single dose of 3,7 mg/kg Cd was injected ip in the morning and Sil was administered in drinking water for 10 days. On the 10th day of the experiment, 72 hours after Cd administration, the rats were sacrificed under anesthesia and the lungs, kidneys and livers of the rats were isolated and Thiobarbituric acid reactive substances (TBARs), GSH, total thiol (T-SH) levels in these tissues were evaluated. Tissue damage was assessed by serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, blood urea nitrogen (BUN) and creatine kinase (CK-MB). It was found that cadmium significantly increased AST, ALT, creatinine, BUN, CK-MB and TBARs levels compared to the control group, and significantly decreased GSH andT-SH levels. In sildenafil + cadmium administration, TBARs levels significantly decreased while GSH and T-SH levels significantly increased compared to cadmium group. The protective effect of sildenafil against multiple organ damage caused by cadmium may be due to its antioxidant properties. © 2020 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.