Yazar "Bener, Mustafa" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Iron(III) and nickel(II) complexes with S-alkyl (n-C1-6)-thiosemicarbazidato ligands: Synthesis, structural characterization, and antioxidant features
    (Elsevier Science Bv, 2018) Kaya, Busra; Sahin, Onur; Bener, Mustafa; Ulkuseven, Bahri
    Six of acetylacetone-S-R-thiosemicarbazones (R: methyl, ethyl, propyl, butyl, pentyl or hexyl) were synthesized, and the template reactions resulting in N2O2 type complexes of the thiosemicarbazones with 4-methoxy-salicylaldehyde were carried out in the presence of iron(III) or nickel(II). The thiosemicarbazones and metal complexes were defined by elemental analysis, and infrared, UV-Vis, H-1 NMR spectra. Three complexes bearing butyl-pentyl- and hexyl-groups were analyzed by X-Ray diffraction technique. The crystal data demonstrated that the iron complexes are in square pyramidal structure and nickel complexes in square planar structure. To explicate the relationship between the S-alkyl chain length and antioxidant ability, total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds have been tested using CUPRAC and DPPH methods, respectively. Furthermore, the antioxidant potential of the thiosemicarbazones were determined in vitro measuring the scavenging activity of hydroxyl radical (center dot OH), superoxide anion radical (center dot O-2(-)), and hydrogen peroxide (H2O2). The results revealed that the compounds have an antioxidant features comparable to ascorbic acid reference. Synthesized compounds with the remarkable antioxidant properties have a potential to examine in development of new anticancer agents. (C) 2018 Elsevier B.V. All rights reserved.
  • [ X ]
    Öğe
    Iron(III) complexes based on tetradentate thiosemicarbazones: Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT cells
    (Wiley, 2021) Kalindemirtas, Ferdane Danisman; Kaya, Busra; Bener, Mustafa; Sahin, Onur; Kuruca, Serap Erdem; Demirci, Tulay Bal; Ulkuseven, Bahri
    Nine iron(III) complexes, [Fe(L)Cl], were synthesized starting from S-alkyl-thiosemicarbazones and some substituted aldehydes. The L ligands formed by template condensation are N2O2-chelating structures and named N-1-acetylacetone-N-4-R-salicylidene-S-alkyl-thiosemicarbazidato (L2-) where alkyl = methyl, propyl, or allyl and R = 3-methoxy, 4-methoxy, or 3,5-dichloro. The complexes were characterized using elemental analysis, IR, and ESI-MS. X-ray diffraction analysis of complex Fe8 (as a representative sample) indicated a square pyramid environment of the iron ion. The cytotoxicity performances of the complexes were determined using chronic myelogenous leukemia (K562), Burkitt's lymphoma (P3HR1), and T-cell leukemia (JURKAT) cell lines. For comparison, the noncancerous cell lines, human umbilical vein endothelial (HUVEC) and diploid fibroblast (3T3), and imatinib as positive control were included in the study. MTT results revealed that complexes Fe2, Fe5, Fe7, and Fe8 with methoxy (OCH3) substituent have remarkable cytotoxic effects on K562 and P3HR1 cells at relatively low concentrations in the ranges of 4.81-14.05 and 5.61-11.98 mu M, respectively. The radical scavenging activities of the complexes were measured for DPPH, superoxide anion (O-2(center dot-)), hydroxyl (center dot OH) radicals, and hydrogen peroxide (H2O2). Complexes Fe2, Fe3, Fe5, and Fe8, which exhibited selective cytotoxicity, were able to compete also with vitamin E in terms of ROS scavenging activities.