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    Molecular and crystal structure of 1-methyl- 5-trifluoromethoxy-1H-indole-2,3-dione 3-[4-(4-methoxyphenyl)thiosemicarbazone]
    (Istanbul Üniversitesi, 2021) Eter, Özge Soylu; Atioglu, Zeliha; Akkurt, Mehmet; Ersanli, Cem Cüneyt; Karali, Nilgün
    Background and Aims: The main purpose of this study is to determine the molecular structure and isomers of the new 1-methyl- 5-trifluoromethoxy-1H-indole-2,3-dione 3-
  • [ X ]
    Öğe
    Molecular and crystal structure of 1-methyl-5-trifluoromethoxy-1H-indole-2,3-dione 3-[4-(4-methoxyphenyl)thiosemicarbazone]
    (Istanbul Univ, Fac Pharmacy, 2021) Eter, Ozge Soylu; Atioglu, Zeliha; Akkurt, Mehmet; Ersanli, Cem Cuneyt; Karali, Nilgun
    Background and Aims: The main purpose of this study is to determine the molecular structure and isomers of the new 1-methyl-5-trifluoromethoxy-1H-indole-2,3-dione 3-[4-(4-methoxyphenyl)thiosemicarbazone] (5) and to prove the 3Z-conformer of the compound 5. Methods: The molecular structure of E- and Z-isomer mixture 5 was confirmed by analytical and spectral data (UV, IR, H-1 NMR, HSQC-2D and MS). The Z-conformer of compound 5 was characterized by NMR spectroscopy and X-ray single crystal diffraction analysis method (SC-XRD). Results: The compound 5 was synthesized by condensation of 1-methyl-5-trifluoromethoxy-1H-indole-2,3-dione (2) with 4-(4-methoxyphenyl)thiosemicarbazide (4). The compound 5 was obtained in two separate forms, crystal and amorphous. It was proved by NMR data and X-ray diffraction findings that the crystal form is the Z-isomer and the amorphous form is a mixture of the E- and Z-isomers. The E- and Z-isomer ratios were determined by H-1 NMR spectroscopy. The crystal structure and molecular interactions of the Z-conformer were determined by X-ray single crystal diffraction analysis. Conclusion: In the crystal, three intramolecular N-H center dot center dot center dot N, N-H center dot center dot center dot O and C-H center dot center dot center dot S hydrogen bonds provided isomer formation. Also, molecular packing was stabilized by intermolecular C-H center dot center dot center dot O hydrogen bonds, the pi-pi stacking interactions and weak CO center dot center dot center dot pi (ring) contacts.
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    Öğe
    Synthesis of some novel indeno[1,2-b]quinoxalin spiro-β-lactam conjugates
    (Pergamon-Elsevier Science Ltd, 2017) Rad, Javad Ameri; Jarrahpour, Aliasghar; Ersanli, Cem Cuneyt; Atioglu, Zeliha; Akkurt, Mehmet; Turos, Edward
    This article reports the synthesis of some new spiro-beta-lactams bearing an indeno[1,2-b]quinoxaline ring system, prepared by a [2 + 2] cycloaddition of ketenes with imines derived from 11-H-indeno[1,2-b] quinoxalin-11-one. The structures of newly synthesized spiro-beta-lactams 2a-i and 3a-i were characterized by FT-IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analyses. The relative stereochemistry of spiro-beta-lactams 2a and 3a was determined unequivocally by X-ray crystallographic studies. (C) 2017 Elsevier Ltd. All rights reserved.