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    Öğe
    Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities
    (Taylor & Francis Ltd, 2014) Caglar, Sema; Adiguzel, Ekrem; Sariboga, Bahtiyar; Temel, Ersin; Buyukgungor, Orhan
    Mononuclear and dinuclear copper(II) complexes [Cu-2(mu-nap)(4)(3-pic)(2)] (1) and [Cu(nap)(2)(H2O)(4-pic)(2)] (2) have been synthesized in the presence of 3-picoline and 4-picoline. Two complexes were characterized by FT-IR, UV-vis spectroscopic methods and their thermal stabilities were determined by TG/DTA/DTG techniques. The crystal structures of 1 and 2 were established by X-ray analysis. X-ray structure analysis has shown that copper(II) has a distorted square-pyramidal geometry. Naproxenate is a bridging ligand in 1 and monodentate in 2. Two complexes have shown catalytic activity on oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone exhibiting saturation kinetics at high substrate concentrations. The complexes were also screened for antimicrobial activity against pathogenic bacteria and fungi. The complexes exhibited antimicrobial activity against Entrococcus faecalis and Candida albicans.
  • [ X ]
    Öğe
    New metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities
    (Taylor & Francis Ltd, 2016) Caglar, Sema; Dilek, Esra; Caglar, Bulent; Adiguzel, Ekrem; Temel, Ersin; Buyukgungor, Orhan; Tabak, Ahmet
    Four new neutral diclofenac-based complexes, [Co(dicl)2(2-pyet)2] 1, [Ni(dicl)2(2-pyet)2] 2, [Cu2(dicl)2(2-pyet)2] 3, and [Cu2(dicl)2(2-pypr)2] 4 have been synthesized and characterized by elemental analysis, FT-IR, thermal analysis. Complexes 1, 3, and 4 have also been characterized by X-ray single-crystal structural analysis. The compounds of Co(II) and Ni(II) have octahedral geometry with two diclofenac and two 2-pyridineethanol ligands in the coordination sphere. The compounds of Cu(II) have square-pyramidal geometry and Cu(II) ions are linked via oxygens to the bridging 2-pyridineethanol or 2-pyridinepropanol ligands. The values acquired by FT-IR are in agreement with the single XRD data. Studies on the thermal properties are reported and the complexes are stable to 196, 216, 215, and 201 degrees C in air, respectively. Two dinuclear Cu(II) complexes have demonstrated catalytic activity on oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone showing saturation kinetics at high substrate concentrations. The diclofenac complexes are investigated as inhibitors of the human cytosolic isoforms hCA I and II. The complexes are good as hCA I inhibitors (Kis of 1.52-55.06M) but only moderately efficient as hCA II inhibitors (Kis of 0.23-5.61M). [GRAPHICS] .