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    Association between rheumatoid arthritis and lung neoplasm; a systematic review and meta-analysis
    (Nickan Research Institute, 2025) Kharazmi, Amir Behnam; Azimi, Sajad Ataei; Nourmohammadi, Atefeh; Salati, Sina; Özbolat, Gülüzar; Rastad, Hamid; Attar, Armin
    Introduction: Lung cancer is one of the most common malignancies in patients with rheumatoid arthritis (RA). Therefore, this study aimed to determine the association between RA and lung neoplasm using a systematic review and meta-analysis. Materials and Methods: This research was conducted according to the PRISMA guidelines. The databases ProQuest, PubMed, Embase, Web of Science, Cochrane, Scopus, and the search engine Google Scholar were searched up to October 8, 2024. Data analysis was performed using STATA 14 software, and P<0.05 was considered statistically significant. Results: A total of 24 cohort studies, comprising 792,699 participants, were evaluated. The results indicated that RA increased the risk of lung neoplasm. Specifically, the hazard ratio (HR) was 1.54 (95% CI: 1.33–1.77), the standardized incidence ratio (SIR) was 1.30 (95% CI: 1.19–1.41), and the risk ratio (RR) was 1.50 (95% CI: 1.31–1.71). RA increased the risk of lung neoplasm in both women (SIR: 1.24; 95% CI: 1.12, 1.39) and men (SIR: 1.71; 95% CI: 1.37, 2.15). No significant statistical association was found between RA and lung neoplasm in patients aged 30-39 years (SIR: 1.40; 95% CI: 0.64, 3.08) and 40-49 years (SIR: 0.64; 95% CI: 0.21, 1.93). However, in patients aged 50-59 years (SIR: 1.31; 95% CI: 1.18, 1.45) and 60-69 years (SIR: 1.63; 95% CI: 1.51, 1.77), RA increased the risk of lung neoplasm. Conclusion: Rheumatoid arthritis was associated with an increased risk of lung neoplasm, and this risk increased with age. The risk of lung neoplasm was higher in men than in women. Therefore, advanced age and male gender were identified as risk factors for lung neoplasm in RA patients. © 2025 The Author(s)
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    Au nanoparticles in the diagnosis and treatment of ovarian cancer: A new horizon in the personalized medicine
    (Tehran University of Medical Sciences, 2022) Zadeh, Firoozeh Abolhasani; Shahhosseini, Elham; Rasoolzadegan, Soheil; Özbolat, Gülüzar; Farahbod, Farnoosh
    As the world's sixth prevalent malignancy among women, the increased rate of mortality in ovarian cancer (OC) patients is due to late diagnosis that causes a high rate of proliferation within the abdominal cavity. The sensitivity of screening and detection methods for the diagnosis of ovarian cancer in the early stages is insufficient. Considering the high rate of ovarian cancers resistance to most traditional treatments that cause the risk of disease recurrence and death, it is necessary to design new treatments and diagnostic methods. In this regard, nanoparticles and nanotechnology can be viable options for suppressing these limitations. One of the goals of nanotechnology is to improve the approaches of diagnosing, treating, or their combination (theranostics) in a variety of diseases including cancer. Au nanoparticles can simultaneously integrate therapeutic and imaging agents due to their special and extraordinary physicochemical properties and function as theranostic platforms. Next to their numerous distinct features, such as small size, surface impacts, quantum size, and electrical and optical effects, AuNPs proved to be relatively secure, stable, and require a simple preparation. Gold nanoparticles can be exerted as carriers for a more effective and targeted diagnostic and therapeutic agent delivery in the treatment of ovarian cancer. They can limit drug toxicity at tumor site and consequently reduce the toxicity of normal cells and tissues. Gold nanoparticles can be used as nano-theranostics agents and facilitate personalized medicine for a more efficient treatment of ovarian cancer by providing the simultaneous delivering of diagnostic and therapeutic agents. © Medicina e Morale.All right reserved.
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    In vitro evaluation of the protective effects of Curcumin and Resveratrol against U87 Cells Induced by Beta-Amyloid
    (Bolu Abant Izzet Baysal Üniversitesi, 2022) Alizade, Ares; Özbolat, Gülüzar
    Objective: In this study we aimed to investigate the effects of curcumin and resveratrol antioxidant enzymes in ß-amyloid (Aß)-induced in vitro Alzheimer's Disease (AD) cell model. Materials and Methods: Three groups were created in this study; The control group consisted of U87 cells, the Aß group which was the in vitro AD model formed from the ß-amyloid-induced U-87 cell lines, and the Aß+ Curcumin+ Resveratrol group by adding curcumin and resveratrol to the Aß group. Cell viability in groups was evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test. Total Antioxidant Level (TAS), Superoxide dismutase (SOD), Total Oxidant Level (TOS), and Catalase (CAT) enzyme levels, results were analyzed in order to evaluate the antioxidant levels.Results: When cell viability was evaluated, it was determined that curcumin and resveratrol did not have cytotoxic effects. TAS levels were statistically higher in the Aß+ curcumin and resveratrol group compared to the Aß group (p<0.05) and TOS levels were found to be significantly low in the Aß+ curcumin and resveratrol group compared to the Aß group (p<0.05). However, when compared to the control group, CAT and SOD enzyme levels were statistically and significantly low in the Aß group. In contrast, these enzyme levels were found significantly higher in the Aß+ curcumin and resveratrol group in comparison with the Aß group (p<0.05).Conclusion: In conclusion, it has been shown that curcumin and resveratrol support antioxidant activity.
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    Silver nanoparticles: biosynthesis and cytotoxic performance against breast cancer MCF-7 and MDA-MB-231 cell lines
    (Tehran University of Medical Sciences, 2022) Darvish, Soodabeh; Kahrizi, Mohammad Saeed; Özbolat, Gülüzar; Khaleghi, Fatemeh; Mortezania, Zohreh; Sakhaei, Delaram
    Objective(s): A study was performed on the possibility of synthesizing silver nanoparticles (Ag-NPs) from Ducrosia Anethifolia Aqueous Extract for treating breast cancer MCF-7 and MDA-MB-231 cell lines. Methods: The application of Ducrosia Anethifolia Aqueous Extract caused a reduction in silver ions and facilitated the production of silver nanoparticles. Different analyzing procedures were exerted to evaluate the qualities of synthesized NPs by Ducrosia Anethifolia Aqueous Extract including UV-Vis spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). In the following, subsequent to assessing the viability of MCF- 7 and MDA-MB-231 cell lines, their exposure to AgNPs was evaluated by the usage of MTT assay. Moreover, the Bax, Bad, Bcl-2, and c-FLIP expression levels of treated cells were examined by real-time PCR analysis. Results: The observance of an absorption peak at 460 nm through the obtained data from a spectrophotometer affirmed the production of silver NPs. The images of electron microscope displayed the spherical shape of NPs in an average size of around 9.41 nm. Moreover, this product caused a robust reduction in the viability of both MCF-7 and MDA-MB-231 cell lines that was mainly pointed out by the improved expressions of Bax and Bad gene, while minimizing the gene expressions of Bcl-2 and c-FLIP. Conclusions: This experiment approved the applicability of Ducrosia Anethifolia Aqueous Extract for performing the green synthesis of NPs. In addition, the synthesized NPs exhibited anti-tumor effects on the applied breast cancer cell lines through the up-regulation of pro-apoptotic proteins concomitant along with the down-regulation of anti-apoptotic proteins expression. © Semina:Ciencias Agrarias.All right reserved.