Sinop Üniversitesi Kurumsal Akademik Arşivi
DSpace@Sinop, Sinop Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The effect of thrombosis-related laboratory values on mortality in COVID-19 infection
(Verduci Publisher, 2023) Ergenc, Z.; Ergenc, H.; Ozturk, A.; Kaya, T.; Nalbant, A.; Karacaer, C.; Gunay, S.
OBJECTIVE: COVID-19 may cause thrombosis in both venous and arterial systems. Familiarity with the signs and symp-toms of thrombosis and its treatment is essen-tial in treating COVID-19 infection and its com-plications. D-Dimer and mean platelet volume (MPV) are measurements related to the devel-opment of thrombosis. This study investigates whether MPV and D-Dimer values could be used to determine the risk of thrombosis and mortali-ty in the COVID-19 early stages.PATIENTS AND METHODS: 424 patients who were COVID-19 positive, according to the World Health Organization (WHO) guidelines, were randomly and retrospectively included in the study. Demographic and clinical character-istics such as age, gender, and length of hospi-talization were obtained from the digital records of participants. Participants were divided into living and deceased groups. The patients' bio-chemical, hormonal, and hematological param-eters were analyzed retrospectively.RESULTS: White blood cells (WBC), neutro-phils, and monocytes were significantly differ-ent in the two groups (p-value <0.001), and their values were lower in the living group than in the deceased group. MPV median values did not dif-fer according to prognosis (p-value = 0.994). While the median value was 9.9 in the survivors, it was 10 in the deceased. Creatinine, procalci-tonin, ferritin, and the number of hospitalization days in living patients were significantly lower than in patients who died (p-value <0.001). Me-dian values of D-dimer (mg/L) differ according to prognosis (p-value <0.001). While the median value was 0.63 in the survivors, it was found as 438 in the deceased.CONCLUSIONS: Our results did not show any significant relationship between the mortality of COVID-19 patients and their MPV levels. How-ever, a significant association between D-Di-mer and mortality in COVID-19 patients was ob-served.
Sprint and Anaerobic Power with the Soccer-Specific ACTN3 Gene: A Distintive Example
(Soc Chilena Anatomia, 2024) Soyler, Mehmet; Zileli, Raif; Ozkamci, Huseyin; Diker, Gurkan; Sever, Mehmet Onur; Bayrakdaroglu, Serdar; On, Sadi
The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur soccer players, and (2) to determine whether there is a difference in the ACTN3 gene polymorphism between professional and amateur soccer players. Ultimately, the goal is to reveal which parameters contribute to the differentiation in these two aspects. A total of 133 volunteer soccer players, including 71 professionals and 62 amateurs, participated in the research. DNA extraction from buccal epithelial cells was performed using a commercial kit to determine the genetic background of the athletes, and Real -Time PCR was conducted for genotyping. Statistical analysis of the findings obtained from the test results was performed using the SPSS 23 (SPSS Inc., Chicago, IL, USA) package program. The homogeneity of variance of the data was assessed using the Levene Test, and normal distribution analyses were conducted using the Shapiro -Wilk Test. Chi-square and Mann -Whitney U tests were employed for parameter analysis. The significance level was set at p<0.05. Evaluation of the data in our study revealed no statistically significant difference in ACTN3 rs1815739 gene polymorphism between the groups (p>0.05). However, there is a statistically significant difference in anaerobic parameters (10m sprint, 30m sprint, and anaerobic power) except for the Illinois test (p<0.05). In conclusion, our study found that gene polymorphism is not a differentiating factor between professional and amateur soccer players, but speed (10m and 30m) and anaerobic power parameters are differentiating factors.
The Distinguishing Factor in Soccer Players is Aerobic Performance, not the ACTN3 Gene
(Soc Chilena Anatomia, 2023) Zileli, Raif; Soyler, Mehmet; Diker, Gurkan; Ozkamci, Huseyin; Bayrakdaroglu, Serdar; Sever, Mehmet Onur; Can, Ibrahim
The purpose of this study was to reveal the differences between ACTN3 genotype (RR, RX, XX) and aerobic performance [Yo-Yo IRT1 (m), VO2 max (ml/kg/min)] in professional and regional amateur league soccer players and to reveal which of these parameters was a distinctive factor in these athletes.71 professional soccer players (age: 23.66 +/- 4.11 years; body height: 1.79 +/- 6.99 m; body weight: 76.02 +/- 6.76 kg; body fat: 11.59 +/- 3.11 %) and 62 regional amateur soccer players (age: 23.63 +/- 3.77 years; body height: 1.81 +/- 5.77 m; body weight: 76.36 +/- 7.53 kg; body fat: 15.60 +/- 4.65 %) volunteered for the study. After DNA extraction from buccal epithelial cells via a commercial kit was performed for the genetic background of the athletes, Real-Time PCR was carried out for genotyping. Furthermore, Yo-Yo IRT1 test was performed to determine the aerobic performance of the soccer players. SPSS 23 (SPSS Inc., Chicago, IL, USA) package program was used for the statistical analysis of the data obtained in the tests. Shapiro-Wilk test for normality and Levene's test for homogeneity of variance were performed. Chi-Square, Independent Sample T Test and One Way ANOVA test were used in the analysis of the parameters. Statistical significance was set as p<0.05. In the study, there found no meaningful statistical significance in terms of the rs1815739 polymorphism in the ACTN3 gene between the groups (p>0.05); however, there was a statistical significance in favor of professional soccer players in terms of aerobic parameters (p<0.05). Consequently, it can be said that aerobic performance is the distinguishing factor, not the ACTN3 gene, in soccer players.
A CASE STUDY: ECOLOGICAL QUALITY STATUS OF SUSURLUK RIVER BASIN (MARMARA SEA)
(Parlar Scientific Publications (P S P), 2019) Albayrak, Serhat; Caglar, Senem; Mulayim, Aysegul; Kurt-Sahin, Guley; Balkis, Husamettin; Cinar, Nur Findik; Atabay, Hakan
This study was carried out with the aim of determining the Ecological Quality Status (EQS) of coastal transitional waters of Susurluk River Basin (Marmara Sea). Macrozoobenthic invertebrate material was collected in May of 2013 from six stations in triplicate by means of a van Veen grab. Shannon-Weaver Diversity Index and associated Pielou's Evenness Index together with biotic indices AMBI and BENTIX were calculated. Some ecological variables (Secchi disc depth, temperature, salinity, dissolved oxygen, pH, total phosphorus, total nitrogen, silica, Chlorophyll-a) of the sea water and total organic carbon of the sediment were also measured. Ecological Quality Status at each station was assessed by considering individual dominancy of sensitive and tolerant species, results from univariate/biotic indexes and some ecological parameters. When EQS of the basin is evaluated as a whole, it was seen that there was not any station in Good or High EQS at the study area, stations were in Poor or Bad EQS at the stations where the River meets the sea, while the stations off the River mouth were in Moderate EQS. Both species pattern of macrozoobenthic invertebrate communities and ecological parameters determined in the basin such as TOC and nutrients present the negative impacts of the River over the basin and indicate the necessity of efficient precautions to be taken.
THE EFFECT OF DIMETHOATE ON CAPOETA CAPOETA (GULDENSTAEDT 1773) AND THE PROTECTIVE EFFECT OF ASCORBIC ACID
(Parlar Scientific Publications (P S P), 2016) Tanriverdi, Erdi Anil; Yilmaz, Muhitdin; Koc, Evren; Akgul, Ali; Ersan, Yusuf
In this study, Dimethoate (DM) (a pesticide)'s histopathological and electrophoretic effects were investigated on Capoeta capoeta (Guldenstaedt 1773) that were captured from Kars creek, and the protective effect of ascorbic acid (AA) (vitamin C) was tested. After allowing time for their adaptations to their new environment, the fish caught from Kars creek were divided into 4 groups (each including 10 fish), and placed in 300-liter tanks in the laboratory. The fish were kept in water containing different solutions: group I in normal water medium, group II in 100 mg/L AA, group III in 2 mg/L DM, and group IV in 100 mg/L AA and 2 mg/L DM. They were kept in these water mediums for 10 days. After this period, blood and tissue samples were taken from the fish for electrophoretic and histopathological studies. Tissue samples were detected in 10% formaldehyde solution and paraffin blocks were prepared by routine histological methods. The samples were cut into sections 3-5 thick, all stained according to hematoxylin and eosin staining methods, and they were examined under a microscope. Obtained serum samples were carried out in Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE). When we compared the serum samples with the control group of fish, protein bands in the application of 100 mg/L AA and 2 mg/L DM, thickening in 36 kD band, thinning in 100 kD, 97 kD, 76 kD, 56 kD and 30 kD bands were observed, and the bands of 93 kD, 46 kD, 44 kD and 26 kD were detected as newly-synthesized in SDS-PAGE electropherogram. In the histopathological examinations, depending on DM in intestine, liver, and kidney tissues obtained from the group formed by application of DM and AA, degeneration, necrosis, pyknotic nuclei and cell infiltrates were detected. As a result, whereas DM application was found to create toxic effects on Capoeta capoeta, AA was found to have a healing effect.
