Kanwal, NosheenKhan, Islam UllahSharif, ShahzadHussain, Erum AkbarMehmood, ArshadSahin, Onur2025-03-232025-03-2320191074-15421572-8854https://doi.org/10.1007/s10870-018-00765-2https://hdl.handle.net/11486/6914Efficient syntheses of four derivatives G2-G5 of Gabapentin (G1) have been achieved. The structures of targeted compounds were investigated by elemental analysis, FT-IR, and H-1-NMR spectroscopic method. Crystal structures of G2 and G4 determined by single crystal X-ray diffraction method are also described. In G2 the molecules are stacked over each other in the form of layers and adjacent layers run parallel to each other. Intermolecular hydrogen bonding and van der Waals interactions are responsible for building the molecular assembly and packing of molecules in the unit. In G4, the molecules are arranged in parallel sheets formed by inter-molecular hydrogen bonds. The proposed synthetic route has high impact due to its simple reaction conditions of room temperature, water as a green solvent and short time to accomplish the reaction.eninfo:eu-repo/semantics/closedAccessGabapentinSulfonamidesSynthesisCrystal structureThermal analysisArticle49316216810.1007/s10870-018-00765-22-s2.0-85059504967Q3WOS:000485397200006Q4