Kural, Birgul VanizorDeger, OrhanErem, CihangirYucesan, Fulya BalabanBarlak, YasamTuran, IbrahimAliyazicioglu, Rezzan2025-03-232025-03-2320130250-46851303-829Xhttps://doi.org/10.5505/tjb.2013.41033https://hdl.handle.net/11486/4520Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.eninfo:eu-repo/semantics/closedAccessmetabolic syndromeLPIN1lipin-1Article38328028510.5505/tjb.2013.41033Q3WOS:000328162700006Q4