Donmez, Selin E.Soydas, EmineAydin, GokcenSahin, OnurBozkaya, UgurTurkmen, Yunus E.2025-03-232025-03-2320191523-70601523-7052https://doi.org/10.1021/acs.orglett.8b03886https://hdl.handle.net/11486/5951A catalytic aza-Nazarov cyclization between 3,4-dihydroisoquinolines and alpha,beta-unsaturated acyl chlorides has been developed to access alpha-methylene-gamma-lactam products in good yields (up to 79%) as single diastereomers. The reactions proceed efficiently when AgOTf is used as an anion exchange catalyst with a 20 mol % loading at 80 degrees C. Computational studies were performed to investigate the reaction mechanism, and the findings support the role of the -TMS group in reducing the reaction barrier of the key cyclization step.eninfo:eu-repo/semantics/closedAccessDirect Imine AcylationOne-PotDiastereoselective SynthesisHeterocyclic ChemistryNitrogen-HeterocyclesSiliconAccessPhotocyclizationDiversityThioureaArticle21255455810.1021/acs.orglett.8b03886309851502-s2.0-85060037134Q1WOS:000456633000044Q1