Cakmak, SukriyeVeyisoglu, Aysel2025-03-232025-03-2320212148-3736https://doi.org/10.31202/ecjse.824619https://search.trdizin.gov.tr/tr/yayin/detay/1128574https://hdl.handle.net/11486/4280Synthesized the heterocyclic amide derivatives (I-IV) were from 2-thiophene acetic acid in two steps. In the first step, the intermediate acylation agent formed and isolated, then subjected to aminolysis and obtained the corresponding amide derivatives. The structures of compounds obtained were characterized by FT-IR,13C NMR,1H NMR, spectroscopies and elemental analysis techniques. The antimicrobial activities of these four compounds against Gram-negative bacteria, Gram-positive bacteria and fungi were investigated using the minimum inhibition concentration method. As a result, compounds (I and III) exhibited better good antibacterial activities against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa compared to the commercially standard antibacterial agent of amoxicillin. © 2021, TUBITAK. All rights reserved.eninfo:eu-repo/semantics/openAccessAcyl chlorideAminolysisAntimicrobial activityHeterocyclic amidesSpectroscopic evaluationArticle8138939610.31202/ecjse.8246192-s2.0-85105077660Q41128574