Kantar, Guenay KayaBalta, NimetSahin, OnurSasmaz, Selami2025-03-232025-03-2320230019-5103https://doi.org/10.56042/ijc.v62i7.3730https://hdl.handle.net/11486/4502Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their & alpha;-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, 1H and 13C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against a-glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant a-glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as & alpha;-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01 & PLUSMN;0.16 and 9.52 & PLUSMN;0.23 & mu;g/mL, respectively.eninfo:eu-repo/semantics/openAccessAzaphthalocyanineVanillina-Glucosidase inhibitionArticle62772873410.56042/ijc.v62i7.37302-s2.0-85169574705N/AWOS:001038274800006Q4