Arshad, Muhammad NadeemSahin, OnurZia-ur-Rehman, MuhammadShafiq, MuhammadKhan, Islam UllahAsiri, Abdullah M.Khan, Sher Bahadar2025-03-232025-03-2320131074-15421572-8854https://doi.org/10.1007/s10870-013-0471-5https://hdl.handle.net/11486/6915Methyl 3-hydroxy-2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate was synthesized in single step through in situ bromination of methyl 2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate using dibenzoyl peroxide & N-bromosuccinamide and was crystallized in acetone-ethyl acetate mixture (1:1). However, crystallization in methanol converted the title compound to methyl 3-methoxy-2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate, an unsymmetrical ether. The titled compound C11H11NO6S (3) crystallized in nonoclinic space group P2(1)/c whereas, the compound C12H13NO6S (4) crystallized in triclinic space group P-1. X-ray studies shows that the molecules of 1 are linked into a one-dimensional framework structure by C-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds, while in 4, intermolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi hydrogen bonds and a pi center dot center dot center dot pi interaction result in the formation of infinite chains running along the [010] and [001] directions.eninfo:eu-repo/semantics/closedAccess1,2-Benzothiazine 1,1-dioxideDibenzoylperoxideN-bromosuccinamideDehydrationUnsymmetrical etherArticle431267167610.1007/s10870-013-0471-52-s2.0-84890461282Q3WOS:000327215300006Q4