Singh, GurjaspreetDevi, SwatiSingh, AkshpreetSharma, SamikshaSharma, DevinaMarkan, PallaviKaur, Harshbir2025-03-232025-03-2320250268-26051099-0739https://doi.org/10.1002/aoc.70081https://hdl.handle.net/11486/7325In the present article, a selective and efficient sensor based on organosilane functionalized graphene oxide nanocomposites has been synthesized for the fluorometric detection of tyrosine (Tyr). The 1,2,3-triazole functionalized organosilane has been synthesized by a condensation reaction between 4-(methylthio) aniline and alkylated benzaldehyde followed by azide-alkyne cycloaddition reaction using Cu (I) catalyst. The synthesized organosilane has been fabricated on graphene oxide nanoparticles and the obtained graphene-functionalized organosilane (GO-Silane) was characterized by FTIR and XRD. The morphology of the nanocomposite film was analyzed using scanning electron microscopy. The photophysical properties of GO-Silane were studied which established its selective sensor for tyrosine with the limit of detection values of 1.04 x 10-8 M with a response time of 8 s. The strong coordinated interactions of GO-Silane for the Tyr have been confirmed from FTIR spectra of the GO-Silane-Tyr complex. The competitive amino acid interference assay successfully demonstrated the selectivity of the nanocomposite sensor.eninfo:eu-repo/semantics/closedAccesschemosensorfluorescencegraphene oxideorganosilanetyrosineArticle39310.1002/aoc.700812-s2.0-85218350853Q1WOS:001426481600001Q2