Singh, GurjaspreetHeenaMeral, SeherMarkan, PallaviKaur, HarshbirGill, Baljinder SinghBaliyan, Deepanjali2026-04-252026-04-2520260022-28601872-8014https://doi.org/10.1016/j.molstruc.2025.144486https://hdl.handle.net/11486/8294This manuscript investigates the synthesis and potential of a silatrane-tethered hydrazone derivative as a multifunctional compound capable of selective metal ion sensing, anticancer activity. The synthesized compound demonstrated high sensitivity and selectivity for Al(III) through UV-Vis and fluorescence spectroscopy with 18.73 and 3.46 nM LOD values, respectively, highlighting its effectiveness as a chemosensor. Additionally, both in-vitro and in-silico studies confirmed its promising anticancer properties. The integration of the silatrane framework with the hydrazone moiety enhanced the stability and optical properties of the compound, positioning it as a versatile candidate for addressing key challenges in environmental monitoring and therapeutic interventions. The results indicate that the silatrane-tethered hydrazone holds significant promise for applications in metal ion detection, cancer treatment, providing a foundation for further exploration and development of multifunctional systems with dual sensing and therapeutic roles.eninfo:eu-repo/semantics/closedAccessAl(III) DetectionAnticancer ActivityIn-vitro StudiesIn-silico StudiesSilatraneArticle135210.1016/j.molstruc.2025.1444862-s2.0-105019640048Q1WOS:001606572700004Q20000-0003-0660-47210000-0002-8627-420X0000-0002-3901-52050000-0002-6090-88090000-0002-6309-8936