Cakmak, OsmanOkten, SalihAlimli, DilekSaddiqa, AishaErsanli, Cem Cuneyt2025-03-232025-03-2320181551-70041551-7012https://doi.org/10.24820/ark.5550190.p010.374https://hdl.handle.net/11486/4804Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. [GRAPHICS] .eninfo:eu-repo/semantics/openAccessNitrationN-oxidation6-bromoquinolineaminoquinolinequinoline N-oxidesmorpholinyl and piperazinyl quinolinesArticle36237410.24820/ark.5550190.p010.3742-s2.0-85049176940Q4WOS:000438799100030Q4